Polyneuropathy

Polyneuropathy involves generalized peripheral nerve dysfunction with symmetric sensory, motor, or autonomic deficits. Etiologies include diabetes, toxins, metabolic disorders, and hereditary conditions. Pathophysiology involves axonal degeneration, demyelination, or ischemic injury. Diagnosis relies on clinical examination, nerve conduction studies, and laboratory evaluation. Management focuses on etiology-specific treatment, symptom control, and rehabilitation; prognosis depends on cause and disease progression.