Miller Fisher Syndrome

Miller Fisher syndrome is a rare variant of Guillain–Barré syndrome characterized by ophthalmoplegia, ataxia, and areflexia. Etiology is autoimmune, often post-infectious, mediated by anti-GQ1b antibodies. Pathophysiology involves peripheral nerve demyelination affecting cranial and peripheral nerves. Diagnosis is clinical, supported by serology and nerve conduction studies. Management includes intravenous immunoglobulin or plasmapheresis; prognosis is generally favorable with most patients recovering fully.