Marchiafava–Bignami Disease

Marchiafava–Bignami disease is a rare demyelinating disorder affecting the corpus callosum, primarily associated with chronic alcoholism. Clinical features include cognitive impairment, dysarthria, seizures, and motor deficits. Pathophysiology involves demyelination and necrosis of the corpus callosum due to malnutrition and alcohol-induced toxicity. Diagnosis relies on MRI showing callosal lesions. Management includes thiamine supplementation, nutritional support, and abstinence from alcohol; prognosis is variable, ranging from partial recovery to severe disability.