Landau–Kleffner Syndrome

Landau–Kleffner syndrome is a rare pediatric epileptic disorder characterized by acquired aphasia and epileptiform EEG abnormalities. Clinical features include language regression, seizure activity (often nocturnal), and behavioral disturbances. Pathophysiology involves epileptic activity disrupting cortical language networks. Diagnosis is based on clinical history, EEG, and neuroimaging to exclude structural lesions. Management includes anticonvulsants, corticosteroids, and speech therapy; prognosis varies, with some children regaining language skills while others experience persistent deficits.