Huntington Disease

Huntington disease is an autosomal dominant neurodegenerative disorder caused by CAG trinucleotide repeat expansion in the HTT gene. Clinical features include chorea, psychiatric disturbances, cognitive decline, and eventual motor disability. Pathophysiology involves striatal and cortical neuronal degeneration with abnormal protein aggregation. Diagnosis is genetic, supported by clinical and imaging findings. Management is symptomatic, including movement disorder control, psychiatric care, and supportive therapy; prognosis is progressive, with reduced life expectancy.