Cocaine Use Disorder

Cocaine use disorder is a chronic, relapsing disorder characterized by compulsive use of cocaine despite adverse social, occupational, or psychological consequences. Etiology involves genetic vulnerability, dopaminergic pathway dysregulation, and environmental influences. Clinically, patients exhibit tolerance, craving, withdrawal symptoms, and persistent use despite functional impairment. Diagnosis requires structured clinical interview and adherence to DSM-5 criteria. Management includes cognitive-behavioral therapy, contingency management, motivational interviewing, and management of comorbid conditions. Prognosis is variable, with higher risk of relapse without sustained intervention.