Cannabis-induced Depressive Disorder

Cannabis-induced depressive disorder arises when cannabis use precipitates depressive symptoms, including low mood, anhedonia, fatigue, and cognitive disturbances. Etiology is linked to dysregulation of monoaminergic and endocannabinoid systems, and genetic vulnerability. Clinically, patients report depressive symptoms temporally correlated with cannabis consumption, often causing social or occupational impairment. Diagnosis requires establishing a temporal relationship between cannabis use and symptom onset, and exclusion of primary depressive disorders. Management emphasizes cessation of cannabis, psychoeducation, psychotherapy, and pharmacologic treatment if clinically indicated. Prognosis improves with abstinence and early intervention, though recurrent use may prolong symptomatology.