Agenesis of The Corpus Callosum

Agenesis of the corpus callosum is a congenital disorder characterized by complete or partial absence of the corpus callosum, the primary commissural fiber tract connecting the cerebral hemispheres. Etiologies include genetic mutations, chromosomal abnormalities, and in utero environmental insults. Clinical presentation is highly variable, ranging from asymptomatic individuals to severe intellectual disability, seizures, and motor or social deficits. Diagnosis relies on neuroimaging, particularly MRI, to delineate callosal morphology and associated brain anomalies. Management is supportive and multidisciplinary, focusing on developmental therapies, seizure control, and educational interventions, with prognosis largely determined by associated anomalies.