Multifocal Motor Neuropathy

MMN is a rare immune-mediated peripheral neuropathy characterized by asymmetric distal limb weakness without sensory loss. Etiology involves anti-GM1 antibodies in many cases. Pathophysiology includes demyelination and conduction block in motor nerves. Diagnosis is based on electrophysiology and serology. Management includes intravenous immunoglobulin; prognosis is favorable with treatment, though some residual weakness may persist.