Hereditary Neuropathy With Liability To Pressure Palsies

This autosomal dominant neuropathy is characterized by recurrent, focal nerve palsies precipitated by minor trauma or compression. Etiology involves mutations in the PMP22 gene affecting peripheral myelin. Clinical features include transient weakness, sensory loss, and neuropathic pain. Diagnosis relies on electrophysiologic studies and genetic testing. Management is supportive, including avoidance of nerve compression and physiotherapy; prognosis is generally favorable with intermittent symptoms.