Distal Hereditary Motor Neuropathy

Distal hereditary motor neuropathy is a group of genetically heterogeneous disorders primarily affecting distal motor neurons, resulting in progressive distal muscle weakness and wasting. Sensory involvement is minimal or absent, distinguishing it from Charcot–Marie–Tooth disease. Diagnosis involves clinical assessment, electromyography, and genetic testing. Management is supportive, including physiotherapy, orthoses, and symptomatic treatment for complications. Prognosis is variable; disease is slowly progressive, often resulting in functional disability in adulthood.