Anti-MOG Associated Disease

Anti-myelin oligodendrocyte glycoprotein (MOG) associated disease is an inflammatory demyelinating CNS disorder characterized by antibodies targeting MOG on oligodendrocytes. Clinical manifestations include optic neuritis, transverse myelitis, and acute disseminated encephalomyelitis, often in relapsing forms. MRI demonstrates demyelinating lesions in optic nerves, spinal cord, or brain. Diagnosis is confirmed by detection of anti-MOG antibodies in serum. Management involves immunotherapy with corticosteroids, IVIG, or disease-modifying agents, with prognosis generally more favorable than aquaporin-4 positive neuromyelitis optica.