Progressive Supranuclear Palsy

PSP is a neurodegenerative tauopathy characterized by early postural instability, vertical gaze palsy, parkinsonism, and cognitive impairment. Pathophysiology involves tau aggregation in basal ganglia, brainstem, and frontal cortex. Diagnosis is clinical, supported by MRI showing midbrain atrophy. Management is symptomatic, including physiotherapy, mobility aids, and limited pharmacologic options; prognosis involves progressive disability and reduced lifespan.