Neurofibromatosis

NF is a genetic disorder causing tumor formation in the nervous system and skin. NF1 presents with café-au-lait spots, neurofibromas, and learning disabilities; NF2 with bilateral vestibular schwannomas. Pathophysiology involves mutations in NF1 or NF2 tumor suppressor genes leading to uncontrolled cell proliferation. Diagnosis is clinical and genetic. Management is multidisciplinary, including surgical removal of tumors, monitoring for complications, and supportive care; prognosis depends on tumor burden and malignancy risk.